Experimental and clinical evidence supports the view that the activation of the renin angiotensin aldosterone system is involved in cardiovascular pathology including hypertension, heart failure, myocardial ischemia, and atherosclerosis. The present volume describes the intricacies involved in these processes, including the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7), and aldosterone on cardiac and vascular functions as well as their involvement in the generation of cardiovascular diseases. Fundamental aspects like intracellular signaling, regulation of cell volume in the failing heart, and the presence of an intracrine renin angiotensin system are discussed. Moreover, the role of the mineralocorticoid receptor as an important c- ponent of the intracrine renin angiotensin system and as a regulator of extracellular action of angiotensin II is described, reinforcing the view that aldosterone inhibitors are helpful in the treatment of heart failure and hypertension. Let us hope the imp- tant topics included here motivate basic and clinical investigators and contribute to the development of new therapeutic approaches for cardiovascular diseases. We want to thank the distinguished authors and Humana Press for the opportunity to publish this important book. Walmor C. DeMello Edward Frohlich v Contents 1 Systemic Versus Local Renin Angiotensin Systems. An Overview ...1 Walmor C. DeMello and Richard N. Re 2 Clinical Import of the Local Renin Angiotensin Aldosterone Systems ...7 Edward D. Frohlich 3 Renin, Prorenin, and the (Pro)Renin Receptor ...15 Genevieve Nguyen and Aurelie Contrepas 4 Local Renin Angiotensin Systems in the Cardiovascular System ...25 Richard N.
Nelson used to be a radical journalist, but now he works for Monad, one of the world's leading corporations. Monad make the Dr Easys, the androids which patrol London's streets: assisting police, easing tensions, calming the populace. But Monad also makes the Red Men - tireless, intelligent, creative and entirely virtual corporate workers - and it's looking to expand the programme. So Nelson is put in charge of Redtown: a virtual city, inhabited by copies of real people going about their daily business, in which new policies, diseases and disasters can be studied in perfect simulation. Nelson finds himself at the helm of a grand project whose goals appear increasingly authoritarian and potentially catastrophic. As the boundaries between Redtown and the real world become ever more brittle, and revolutionary factions begin to align themselves against the Red Men, Nelson finds himself forced to choose sides: Renin Angiotensin System and Cardiovascular Disease download ebook pdf Monad or his family, the corporation or the community, the real or the virtual.
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Author: Walmor Demello,Edward D. Frohlich
Number of Pages: 300 pages
Published Date: 03 Mar 2012
Publisher: Humana Press Inc.
Publication Country: Totowa, NJ, United States
Language: English
ISBN: 9781617796388
Download Link: Click Here
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